Annotation Studio: Multimedia Annotation for Students

Annotation Studio is a web-based annotation application that integrates a powerful set of textual interpretation tools behind an interface that makes using those tools intuitive for undergraduates. Building on students’ new media literacies, this Open-source application develops traditional humanistic skills including close reading, textual analysis, persuasive writing, and critical thinking. Initial features of the Annotation Studio prototype, supported by an NEH Start-Up Grant, include aligned multi-media annotation of written texts, user-defined sharing of annotations, and grouping of annotation by self-defined tags to support interpretation and argument development. The fully developed application will support annotation of image, video and audio documents; annotation visualization; export of texts with annotations; and a media repository. We will also identify best practices among faculty using Annotation Studio in a broad range of humanities classes across the country

Annotation Studio: multimedia text annotation for students

Annotation Studio will be a web-based application that actively engages students in interpreting literary texts and other humanities documents. While strengthening students' new media literacies, this open source web application will develop traditional humanistic skills including close reading, textual analysis, persuasive writing, and critical thinking. Initial features will include: 1) easy-to-use annotation tools that facilitate linking and comparing primary texts with multi-media source, variation, and adaptation documents; 2) sharable collections of multimedia materials prepared by faculty and student users; 3) multiple filtering and display mechanisms for texts, written annotations, and multimedia annotations; 4) collaboration functionality; and 5) multimedia composition tools. Products of the start-up phase will include a working prototype, feedback from students and instructors, and a white paper summarizing lessons learned

Identification of C-C Chemokine Receptor 1 (CCR1) as the Monocyte Hemofiltrate C-C Chemokine (HCC)-1 Receptor

Hemofiltrate C-C chemokine (HCC)-1 is a recently cloned C-C chemokine that is structurally similar to macrophage inflammatory protein (MIP)-1α. Unlike most chemokines, it is constitutively secreted by tissues and is present at high concentrations in normal human plasma. Also atypical for chemokines, HCC-1 is reported not to be chemotactic for leukocytes. In this paper, we have investigated the chemokine receptor usage and downstream signaling pathways of HCC-1. Cross-desensitization experiments using THP-1 cells suggested that HCC-1 and MIP-1α activated the same receptor. Experiments using a panel of cloned chemokine receptors revealed that HCC-1 specifically activated C-C chemokine receptor (CCR)1, but not closely related receptors, including CCR5. HCC-1 competed with MIP-1α for binding to CCR1-transfected cells, but with a markedly reduced affinity (IC50 = 93 nM versus 1.3 nM for MIP-1α). Similarly, HCC-1 was less potent than MIP-1α in inducing inhibition of adenylyl cyclase in CCR1-transfected cells. HCC-1 induced chemotaxis of freshly isolated human monocytes, THP-1 cells, and CCR1-transfected cells, and the optimal concentration for cell migration (100 nM) was ∼100-fold lower than that of MIP-1α (1 nM). These data demonstrate that HCC-1 is a chemoattractant and identify CCR1 as a functional HCC-1 receptor on human monocytes

Influence de la taille et dea la saison de pêche sur les qualités organoleptiques des palourdes de l'atlantique (spisula solidissima) et la volonté à payer du consommateur

Dans un marché de libre concurrence, certains paramètres tels que la saison de pêche et la taille des produits halieutiques ont une très grande importance sur la fixation des prix et la volonté à payer du consommateur. Afin de valider ces données, des échantillons de palourdes de l'Atlantique (Spisula solidissima), pêchés dans la zone 4T du Fleuve Saint-Laurent durant trois périodes différentes de l'année, ont été repartis en quatre classes de taille et soumis après cuisson aux membres d'un Jury semi - entraîné pour des tests d'évaluation organoleptique. La tendreté et la saveur des palourdes de taille petite et moyenne ont été préférées a celle de taille plus grande. De plus les échantillons d'été et d'automne sont meilleurs au goût que ceux de printemps. Alors que la période de pêche et la taille des individus n'ont pas d'influence significative sur la composition proximale (teneur en humidité, protéine et lipides), la composition en acides aminés libres responsables de la saveur des produits marins varie de façon significative entre les parties anatomiques de la palourde. Quant a la volonté a payer du consommateur, elle est beaucoup moins forte pour les palourdes de printemps et celles de plus grande taille.Keywords: Clams, Size, Demand, Willingness-to-pay, Consumers, Flavou

Le Forum, Vol. 40 No. 2

https://digitalcommons.library.umaine.edu/francoamericain_forum/1087/thumbnail.jp

Le FORUM, Vol. 35 No. 2

https://digitalcommons.library.umaine.edu/francoamericain_forum/1030/thumbnail.jp

Are chest compressions safe for the patient reconstructed with sternal plates? Evaluating the safety of cardiopulmonary resuscitation using a human cadaveric model

<p>Abstract</p> <p>Background</p> <p>Plate and screw fixation is a recent addition to the sternal wound treatment armamentarium. Patients undergoing cardiac and major vascular surgery have a higher risk of postoperative arrest than other elective patients. Those who undergo sternotomy for either cardiac or major vascular procedures are at a higher risk of postoperative arrest. Sternal plate design allows quick access to the mediastinum facilitating open cardiac massage, but chest compressions are the mainstay of re-establishing cardiac output in the event of arrest. The response of sternal plates and the chest wall to compressions when plated has not been studied. The safety of performing this maneuver is unknown. This study intends to demonstrate compressions are safe after sternal plating.</p> <p>Methods</p> <p>We investigated the effect of chest compressions on the plated sternum using a human cadaveric model. Cadavers were plated, an arrest was simulated, and an experienced physician performed a simulated resuscitation. Intrathoracic pressure was monitored throughout to ensure the plates encountered an appropriate degree of force. The hardware and viscera were evaluated for failure and trauma respectively.</p> <p>Results</p> <p>No hardware failure or obvious visceral trauma was observed. Rib fractures beyond the boundaries of the plates were noted but the incidence was comparable to control and to the fracture incidence after resuscitation previously cited in the literature.</p> <p>Conclusions</p> <p>From this work we believe chest compressions are safe for the patient with sternal plates when proper plating technique is used. We advocate the use of this life-saving maneuver as part of an ACLS resuscitation in the event of an arrest for rapidly re-establishing circulation.</p

Le Forum, Vol. 40 No. 3

https://digitalcommons.library.umaine.edu/francoamericain_forum/1088/thumbnail.jp

F.A.R.O.G. FORUM, Vol. 2 No. 11

https://digitalcommons.library.umaine.edu/francoamericain_forum/1010/thumbnail.jp

Le FORUM, Vol. 38 No. 2

https://digitalcommons.library.umaine.edu/francoamericain_forum/1041/thumbnail.jp